CONTROL OF MOS BY ANTIBIOTICS..

4)  INHIBITION OF SPECIFIC ENZYME SYSTEM:
     


Sulfonamides are synthetic antimicrobial agents that contains sulfonamides group. It targets bacterial metabolic pathways. In bacteria, sulfonamides acts as competitive inhibitor of the enzyme dihydropteroate synthetase(DHPS),an enzyme responsible for folate synthesis. Due to this microorganisms get starved of folate & dies.
To know please visit these links:
http://en.wikipedia.org/wiki/Sulfonamide_(medicine)
http://en.wikipedia.org/wiki/Enzyme_inhibitor
http://www.chemeddl.org/alfresco/service/org/chemeddl/ttoc/ttoc_results/?id=22037&num_results=3&guest=true
http://www.elmhurst.edu/~chm/vchembook/651enzymeinhibit.html
http://www.cs.stedwards.edu/chem/Chemistry/CHEM43/CHEM43/Antibiotics/Antibiotics.HTML
http://www.elmhurst.edu/~chm/vchembook/653sulfa.html


Fig: Enzyme Inhibitors


Fig: Mutant HIV protease Enzyme











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