CONTROL OF MOS BY ANTIBIOTICS
3). Chloramphenicol : Chloramphenicol is considered as pro typical broad spectrum antibiotics alongside tetracycline & is effective against a wide variety of Gram positive & Gram negative bacteria, most anaerobic microorganisms.
Mechanism of Action:
Chloramphenicol is a bacteriostatic antibiotic that stops bacterial growth by inhibiting protein synthesis. It prevents protein chain elongation by inhibiting the peptidyl transferase activity of bacterial ribosome. It specifically binds to A2451& A2452 residues in the 23S r RNA of 50S ribosomal unit, preventing polypeptide formation. It directly interferes substrate binding . To know more please donot bother to visit the following links: