ANTIFUNGAL DRUGS

ANTIFUNGAL DRUGS:

                     


3) Amphotericin B:  It is a polyene antifungal drugs often used intravenously for systemic fungal infections. It was originally extracted from Streptomyces nodosus, a filamentous bacterium. Oral preparations of  amphotericin b is used to treat thrush, these are virtually nontoxic in contrast to typical intravenous therapy doses. It is also commonly used in tissue culture to prevent fungi from contaminating cell cultures. It is antiprotozoal drug also( used to treat parasitic protozoan  infections such as visceral leishmaniasis & primary amoebic meningoencephalitis).

Mechanism of Action:

As with other polyene antifungals, amphotericin b binds with ergosterol , a component of fungal cell membranes, forming  transmembrane channel that leads to  monovalent ions(Potassium,  hydrogen, chloride, sodium ions) leakage, which is  primary effect for fungal death. The actual mechanism may be complexed & multifaceted.

Please visit these links too:
http://en.wikipedia.org/wiki/Amphotericin_B
http://www.nlm.nih.gov/medlineplus/druginfo/meds/a682643.html
http://www.drugs.com/pro/amphotericin-b.html





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