3) Amphotericin B: It is a polyene antifungal drugs often used intravenously for systemic fungal infections. It was originally extracted from Streptomyces nodosus, a filamentous bacterium. Oral preparations of amphotericin b is used to treat thrush, these are virtually nontoxic in contrast to typical intravenous therapy doses. It is also commonly used in tissue culture to prevent fungi from contaminating cell cultures. It is antiprotozoal drug also( used to treat parasitic protozoan infections such as visceral leishmaniasis & primary amoebic meningoencephalitis).
Mechanism of Action:
As with other polyene antifungals, amphotericin b binds with ergosterol , a component of fungal cell membranes, forming transmembrane channel that leads to monovalent ions(Potassium, hydrogen, chloride, sodium ions) leakage, which is primary effect for fungal death. The actual mechanism may be complexed & multifaceted.
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