CONTROL OF MOS BY ANTIBIOTICS...
Certain antibiotics produced by Bacillus spp can cause the damage to cytoplasmic membrane & cause leakage from the cytoplasmic membrane of the cell. The antibiotics included are Polymyxins, Gramicidins, Tyrocidine, Polyenes .http://www.ncbi.nlm.nih.gov/pubmed/15508894
- Polymyxin: Polymyxins are antibiotics, with a general structure consisting of a cyclic peptide with a long hydrophobic tail. They disrupt the structure of the bacterial cell membrane by interacting with its phospholipids. They are produced by nonribosomal peptide synthetase systems in Gram-positive bacteria such as Paenibacillus polymyxa and are selectively toxic for Gram-negative bacteria due to their specificity for the lipopolysaccharide molecule that exists within many Gram-negative outer membranes.Polymyxins B and E (also known as colistin) are used in the treatment of Gram-negative bacterial infections. The global problem of advancing antimicrobial resistance has led to a renewed interest in their use recently.Polymyxin M is also known as "mattacin". To know about polymyxins visit the link: www.ncbi.nlm.nih.gov/pubmed/17420197