CONTROL OF MOS BY ANTIBIOTICS


1) INHIBITION OF CELL WALL SYNTHESIS


  • Vancomycin: Vancomycin is a glycopeptide antibiotics produced by Streptomyces orientalis & used in prophylaxis & treatment of infections caused by Gram positive bacteria.  Vancomycin was first isolated in 1953 at Eli Lilly, from a soil sample collected from the interior jungles of Borneo by a missionary. It is a naturally occurring antibiotic made by the soil bacterium Actinobacteria species Amycolatopsis orientalis (formerly designated Nocardia orientalis). It is a complex chemical compound and an example of a comparatively rare halo organic natural compound, containing two covalently bonded chlorine atoms. The compound was industrially produced by fermentation and given the generic name vancomycin, derived from the term "vanquish." The original indication for vancomycin was for the treatment of penicillin-resistant Staphylococcus aureus, a use kept alive for many years by the fact that compound had to be given intravenously and was thus not abused outside hospitals, and the fact that organisms were relatively slow to evolve to adapt to it, even in experiments. 
Please visit these links:
 http://en.wikipedia.org/wiki/Vancomycin 
http://www.nlm.nih.gov/medlineplus/druginfo/meds/a604038.html



                                                  Fig: Mode of action 

                                                     Fig: Vancomycin modules
Please don't bother to see the video from this link http://www.youtube.com/watch?v=BbtwNNe-lp4 


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