2) Griseofulvin: It is an antifungal drug that is administered orally. It is used both in animals & in humans, to treat fungal infection of skin & nails . It is produced by the culture of some strains of Penicillium griseofulvum.
The drugs binds to tubulin ,interfering microtubule function, thus inhibiting mitosis. It binds to keratin in keratin precursor cells & makes them resistant to fungal infections. It is only when hair or skin is replaced by keratin griseofulvin complex that the drug reaches its site of action. Griseofulvin will then enter the dermatophyte through energy dependent transport processes & bind to fungal microtubules. This alters the processing for mitosis & also underlying information for deposition of fungal cell walls.
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